Shinichi Kitada Selected Research

apogossypol

5/2010	BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
7/2009	Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
4/2009	Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
3/2008	Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

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Shinichi Kitada Research Topics

Disease

23	Neoplasms (Cancer) 08/2013 - 02/2002
11	Leukemia 11/2010 - 02/2002
9	Prostatic Neoplasms (Prostate Cancer) 08/2013 - 07/2002
9	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 03/2007 - 02/2002
5	Lymphoma (Lymphomas) 01/2011 - 04/2003
3	B-Cell Lymphoma (Lymphoma, B Cell) 11/2010 - 07/2009
2	Carcinogenesis 07/2012 - 09/2003
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2006 - 03/2003
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 11/2006 - 06/2005
2	Melanoma (Melanoma, Malignant) 12/2003 - 01/2002
2	Infections 06/2003 - 01/2002
1	Kidney Neoplasms (Kidney Cancer) 01/2013
1	Adenocarcinoma 07/2012
1	Prostatic Intraepithelial Neoplasia 07/2012
1	Lung Neoplasms (Lung Cancer) 01/2011
1	Multiple Myeloma 05/2008
1	Splenomegaly 03/2008
1	Disease Progression 03/2007
1	Stroke (Strokes) 08/2004
1	Hypersensitivity (Allergy) 08/2004
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2003
1	Carcinoma (Carcinomatosis) 11/2003
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 02/2002

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 11/2010 - 01/2002
7	Pharmaceutical PreparationsIBA 01/2013 - 01/2004
7	CaspasesIBA 06/2008 - 02/2002
4	apogossypolIBA 05/2010 - 03/2008
3	Peptide Hydrolases (Proteases)FDA Link 06/2008 - 04/2003
2	Peptides (Polypeptides)IBA 01/2013 - 10/2008
2	Antineoplastic Agents (Antineoplastics)IBA 01/2013 - 05/2010
2	1,1',6,6',7,7'- hexahydroxy- 3,3'- dimethyl- N5- (2- phenylpropyl)- N5'- (2- phenylpropyl)- 2,2'- binaphthyl- 5,5'- dicarboxamideIBA 07/2012 - 05/2010
2	Hormones (Hormone)IBA 01/2011 - 11/2003
2	Biological ProductsIBA 11/2010 - 06/2008
2	ABT-737IBA 11/2006 - 06/2005
2	Death Domain ReceptorsIBA 08/2004 - 03/2002
2	PolyphenolsIBA 12/2003 - 09/2003
2	InterleukinsIBA 12/2003 - 06/2003
2	Rituximab (Mabthera)FDA Link 04/2003 - 02/2002
2	Complement System Proteins (Complement)IBA 04/2003 - 02/2002
2	Immunologic Factors (Immunomodulators)IBA 02/2002 - 02/2002
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2013
1	Transforming Growth Factors (Transforming Growth Factor)IBA 07/2012
1	Transforming Growth Factor-beta Type II ReceptorIBA 07/2012
1	navitoclaxIBA 01/2011
1	MutagensIBA 01/2011
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2011
1	BI97D6IBA 01/2011
1	apogossypoloneIBA 11/2010
1	Amino Acids FDA Link 10/2008
1	gambogic acidIBA 06/2008
1	GossypolIBA 03/2008
1	Immunoglobulin Variable RegionIBA 03/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2005
1	LigandsIBA 08/2005
1	Mitogen-Activated Protein KinasesIBA 08/2005
1	Mitogen-Activated Protein Kinase 3IBA 08/2005
1	B-Cell Activating FactorIBA 08/2005
1	Chemokine CXCL12IBA 08/2005
1	TunicamycinIBA 08/2004
1	ThapsigarginIBA 08/2004
1	Brefeldin AIBA 08/2004
1	TeaIBA 12/2003
1	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium SaltIBA 12/2003
1	Bongkrekic AcidIBA 12/2003
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2003
1	AntioxidantsIBA 12/2003
1	Acetylcysteine (Siran)FDA LinkGeneric 12/2003
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2003
1	Histone Deacetylases (Histone Deacetylase)IBA 07/2003
1	Histones (Histone)IBA 07/2003
1	romidepsin (FK228)FDA Link 07/2003
1	DepsipeptidesIBA 07/2003
1	Chemokine ReceptorsIBA 06/2003
1	Interleukin-15 (Interleukin 15)IBA 06/2003
1	Cytochromes c (Cytochrome c)IBA 04/2003
1	Caspase 8 (Caspase-8)IBA 04/2003
1	Granzymes (Granzyme)IBA 04/2003
1	Antisense OligonucleotidesIBA 09/2002
1	OligonucleotidesIBA 09/2002
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 07/2002
1	CD40 Ligand (CD40L)IBA 03/2002
1	Monoclonal AntibodiesIBA 02/2002
1	fludarabineIBA 02/2002
1	Caspase 3 (Caspase-3)IBA 02/2002
1	Caspase 9IBA 02/2002
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 02/2002
1	mezereinIBA 01/2002
1	Messenger RNA (mRNA)IBA 01/2002
1	Protein Kinase CIBA 01/2002
1	Interferon-betaIBA 01/2002
1	interleukin-24 (ST16)IBA 01/2002

Therapy/Procedure

14	Therapeutics 08/2013 - 01/2002
3	Aftercare (After-Treatment) 07/2002 - 01/2002
2	Drug Therapy (Chemotherapy) 03/2003 - 02/2002
1	Chemoprevention 12/2003
1	Induction Chemotherapy 03/2003
1	Ligation 03/2002